benzhydryl 3-hydroxybutanoate

Base Information

• Chemical Name: benzhydryl 3-hydroxybutanoate
• CAS No.: 1313990-75-8
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 1313990-75-8.mol

Synonyms:benzhydryl 3-hydroxybutanoate

Chemical Property of benzhydryl 3-hydroxybutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzhydryl 3-hydroxybutanoate

There total 2 articles about benzhydryl 3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenylmethyl 3-oxobutanoate (39567-17-4) → benzhydryl 3-hydroxybutanoate (1313990-75-8)

Guidance literature:

With [RuCl(benzene)(rac)-SunPhos]Cl; hydrogen; In ethanol; at 70 ℃; under 15001.5 Torr;

DOI:10.1021/ol201406w

Reference yield:

benzhydryl (R)-3-hydroxy-2-methylene-5-phenylpentanoate → benzhydryl 3-hydroxybutanoate (1313990-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol

2: dmap / 20 °C

3: sodium tetrahydroborate / ethanol / 0.25 h / 0 °C

With dmap; sodium tetrahydroborate; sodium methylate; In methanol; ethanol;

DOI:10.1021/acs.joc.5b00073

Reference yield:

benzhydryl 3-hydroxybutanoate (1313990-75-8) + propionic acid anhydride (123-62-6) → benzhydryl 3-(propionyloxy)butanoate

Guidance literature:

With potassium carbonate; Tetramisole; In di-isopropyl ether; at 20 ℃;

DOI:10.1021/acs.joc.5b00073

upstream raw materials:

diphenylmethyl 3-oxobutanoate