13140-79-9Relevant academic research and scientific papers
Protonation and Anion Binding Properties of Aromatic Bis-Urea Derivatives—Comprehending the Proton Transfer
Bari?i?, Dajana,Cindro, Nikola,Kulcsár, Marina Juriba?i?,Tireli, Martina,U?arevi?, Krunoslav,Bregovi?, Nikola,Tomi?i?, Vladislav
supporting information, p. 4695 - 4706 (2019/03/13)
A series of aromatic bis-urea derivatives was prepared and their proton dissociation, as well as anion binding properties in DMSO were investigated. To this end, UV/Vis and 1H NMR spectroscopies and computational methods were employed. The synt
Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives
Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav
, (2018/12/11)
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
Synthesis and stacked conformations of symmetrical and unsymmetrical oligo-ureas of metaphenylenediamine
Clayden, Jonathan,Lemiegre, Loic,Helliwell, Madeleine
, p. 2302 - 2308 (2008/02/01)
The addition of substituted anilines to nitro-substituted isocyanates followed by reduction generates new aniline-substituted ureas, which can be further extended in a one- or two-directional iterative manner to form oligomeric ureas based on a m-phenylen
