1314095-66-3

Basic information

• Product Name: 4-(naphthalen-1-yl)-2-phenylpyrimidine
• Synonyms: 4-(naphthalen-1-yl)-2-phenylpyrimidine
• CAS NO: 1314095-66-3
• Molecular Weight: 282.345
• Mol File: 1314095-66-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(naphthalen-1-yl)-2-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(naphthalen-1-yl)-2-phenylpyrimidine(1314095-66-3)
• EPA Substance Registry System: 4-(naphthalen-1-yl)-2-phenylpyrimidine(1314095-66-3)

Safety Data

• Hazardous Substances Data: 1314095-66-3(Hazardous Substances Data)

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 1670-14-0 benzamidine monohydrochloride 
• 66-77-3 1-naphthaldehyde 
• 121-44-8 triethylamine 
• 2489-86-3 1-allylnaphthalene 
• 1504-73-0 3-(1-naphthyl)acrolein 
• 618-39-3 benzamidin 
• 405064-45-1 1-(naphthalen-1-yl)-3-(trimethylsilyl)prop-2-yn-1-ol 
• 1791-23-7 1-(1'-naphthyl)-2-propyn-1-ol 

Relevant articles and documents

Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N, N-Dimethylaminoethanol as One Carbon Donor

An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed. It involves a [3 + 2 + 1] three-component annulation of amidines, ketones, and one carbon source. N,N-Dimethylaminoethanol is oxidized through C(sp3)-H activation to provide the carbon donor. One C-C and two C-N bonds are formed during the oxidative annulation process. The reaction shows good tolerance to many important functional groups in air, making this methodology a highly versatile alternative, and significant improvement to the existing methods for structuring a pyrimidine framework, especially 4-aliphatic pyrimidines.

Synthesis method of pyrimidine compound containing alkyl and aryl

The invention discloses a synthesis method of a pyrimidine compound containing alkyl and aryl, and belongs to the technical field of organic synthesis. Key points of the technical scheme of the invention are as follows: the synthesis method of the pyrimidine compound containing alkyl and aryl comprises the following specific steps: dissolving an aldehyde compound, an amidine hydrochloride compoundand a tertiary aliphatic amine compound in a solvent, adding an iodine reagent and an oxidant, and carrying out a reaction process at 110-150 DEG C to prepare the pyrimidine compound containing alkyland aryl as a target product. The synthesis process is simple and efficient, the pyrimidine compound is directly prepared by one step through a one-pot cascade reaction without transition metal catalysis so that resource waste and environmental pollution caused by use of various reagents in multi-step reaction, purification treatment of reaction intermediates in each step and the like are avoided, the synthesis process is convenient to operate, the raw materials are simple, the reaction conditions are mild, the substrate application range is wide, and meanwhile, alkyl substituents are ingeniously introduced by taking the tertiary fatty amine compound as the raw material.

Transition Metal Free Intermolecular Direct Oxidative C-N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant

Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C-N bond formation of allylic C(sp3)-H and vinylic C(sp2)-H of allyllic compounds with amidines using O2 as the sole oxid