1314123-75-5Relevant academic research and scientific papers
Synthesis of (-)-okilactomycin by a prins-type fragment-assembly strategy
Tenenbaum, Jason M.,Morris, William J.,Custar, Daniel W.,Scheidt, Karl A.
, p. 5892 - 5895 (2011/08/04)
All things converge: A highly convergent synthesis of (-)-okilactomycin utilizes a Prins-type Maitland-Japp cyclization for the fragment assembly of two complex intermediates (see scheme). The synthesis also employs a highly diastereoselective Lewis acid promoted Diels-Alder reaction and an olefin ring-closing metathesis to close a strained 11-membered macrocycle.
