1314161-94-8Relevant articles and documents
Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists
Baker, James,Bingham, Matilda,Blackburn-Munro, Ruth,Cai, Jiaqiang,Craighead, Mark,Gilfillan, Robert,Goan, Kate,Jaap, David,Milne, Rachel,Richard Morphy,Napier, Susan,Presland, Jeremy,Spinks, Gayle,Thomson, Fiona
scheme or table, p. 3603 - 3607 (2011/08/06)
The synthesis and preliminary structure-activity relationships (SAR) of a novel class of vasopressin V1B receptor antagonists are described. Hit compound 5, identified via high throughput screening of the corporate collection, showed good activity in a V1B binding assay (K i 63 nM) but did not possess the lead-like physicochemical properties typically required in a hit compound. A 'deletion approach' on the HTS hit 5 was performed, with the focus on improvement of physicochemical properties, yielding the selective V1B antagonist 9f (Ki 190 nM), with improved druglike characteristics.
