13142-83-1

Usage

Uses

Used in Agricultural and Forestry Industries:
1-(3-methoxyphenyl)-3-phenylurea is used as a herbicidal agent for the control and management of a wide range of broadleaf weeds and grasses. It is particularly effective in non-crop areas and forestry settings, where it helps maintain the health and productivity of the land by preventing the overgrowth of unwanted vegetation.
The application reason for using 1-(3-methoxyphenyl)-3-phenylurea in these industries is its ability to target and inhibit the ALS enzyme in plants, which is essential for the biosynthesis of branched-chain amino acids. By disrupting this process, the herbicide effectively controls weed growth without causing significant harm to the environment or non-target species, given that it has low toxicity to birds, fish, and mammals. However, it is important to be cautious of its potential risk to aquatic organisms and to follow proper application protocols to minimize any adverse effects.

Upstream product

• 536-90-3 m-Anisidine 
• 582-61-6 benzoyl azide 
• 62-53-3 aniline 
• 18908-07-1 3-methoxyphenyl isocyanate 
• 6136-67-0 3-methoxybenzophenone 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 13142-80-8 1-(3-hydroxyphenyl)-3-phenylurea 

Relevant academic research and scientific papers

An Improved Synthesis of Urea Derivatives from N -Acylbenzotriazole via Curtius Rearrangement

The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N -acyl, and cyclic ureas in good yields from N -acylbenzotriazoles by treating the latter with various amines in the presence of TMSN 3 /Et 3 N in a sealed tube. The salient features of the devised protocol includes the high-yield, mild, metal-free, one-pot reaction conditions, and short reaction time. Furthermore, in many cases, no column chromatography is required for the purification.

Synthetic method and application of urea compound

The invention relates to a synthetic method of a urea compound, comprising the following steps: adding substituted oxazolone and sodium acetate into a methanol solution, and adding substituted amine under the stirring condition, reacting and carrying out column chromatography to obtain the urea compound. The defect that dangerous compounds need to be used during existing synthetic process is overcome, and a one-pot method is adopted to replace an existing reaction with low yield. The method of the invention has mild reaction condition, the operation is simple, raw materials are easily available, and the substrate can be converted into various other useful molecules. The compound has strong practicality, and can be applied to synthesis of the pesticide daimuron, dieresis long and the anti-cancer drug Sorafenib. The invention relates to a green and environmentally-friendly unsymmetrical urea compound synthesis method with simple process and low cost.

An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds

An efficient conversion of carbonyl compounds (aldehydes and ketones) to nitrile, tetrazole, and urea was developed with the use of a POCl3 and sodium azide mixture using a convergent and microwave method. This is the first report on the direct conversion of ketone to urea. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass and IR spectroscopies and were found to be in agreement with reported compounds.

Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea

Tuberculosis is a major threat for mankind and the emergence of resistance strain of Mycobacterium tuberculosis (Mtb) against first line antibiotics makes it lethal for human civilization. In this study, we have synthesized different diaryl urea derivativ

Thiol on silica as a 'catch and release' support for isocyanates to afford ureas

Silica-bound thiocarbamates were prepared by Curtius rearrangement of carboxylic acids in the presence of thiol on silica gel. The solid supported thiocarbamates were found to be stable isocyanate equivalents, which upon treatment with amines efficiently afforded di- and tri-substituted ureas. The urea products released from the catch and release support were, in the majority of cases, greater than 95% pure and required no further work up.