13143-66-3

Basic information

• Product Name: N-[(5-methyl-2-propan-2-yl-cyclohexylidene)amino]pyridine-4-carboxamide
• CAS NO: 13143-66-3
• Molecular Formula: C₁₆H₂₃N₃O
• Molecular Weight: 273.378
• Mol File: 13143-66-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.12g/cm³
• CAS DataBase Reference: N-[(5-methyl-2-propan-2-yl-cyclohexylidene)amino]pyridine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(5-methyl-2-propan-2-yl-cyclohexylidene)amino]pyridine-4-carboxamide(13143-66-3)
• EPA Substance Registry System: N-[(5-methyl-2-propan-2-yl-cyclohexylidene)amino]pyridine-4-carboxamide(13143-66-3)

Safety Data

• Hazardous Substances Data: 13143-66-3(Hazardous Substances Data)

Upstream product

• 89-78-1 menthol 
• 54-85-3 isoniazid 
• 491-07-6 (+/-)-menthone 

Relevant articles and documents

Menthone aryl acid hydrazones: A new class of anticonvulsants

A series of ten compounds (Compounds J1-J10) of (±) 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds were evaluated for anticonvulsant activity after intraperitoneal (i.p) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure method and minimal clonic seizure test. Minimal motor impairment was also determined for these compounds. Results obtained showed that four compounds out of ten afforded significant protection in the minimal clonic seizure screen at 6 Hz. Compound J6, 4-Chloro-N-(2-isopropyl-5- methylcyclohexylidene) benzohydrazide was found to be the most active compound with MES ED50 of 16.1 mg/kg and protective index (pI) of greater than 20, indicating that (±) 3-menthone aryl acid hydrazone possesses better and safer anticonvulsant properties than other reported menthone derivatives viz. menthone Schiff bases, menthone semicarbazides and thiosemicarbazides.