131434-98-5Relevant academic research and scientific papers
α-Hydroxy Phosphinyl-Based Inhibitors of Human Renin
Patel, Dinesh V.,Rielly-Gauvin, Katherine,Ryono, Denis E.,Free, Charles A.,Rogers, W. Lynn,et al.
, p. 4557 - 4569 (2007/10/02)
The design and application of α-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel and potent inhibitors of the aspartyl protease renin is described.Tripeptidic α-hydroxy diethyl phosphonate 3, the first example i
Preparation of peptidic α-hydroxy phosphonates. A new class of transition state analog renin inhibitors
Patel,Rielly-Gauvin,Ryono
, p. 5587 - 5590 (2007/10/02)
A stereoselective synthesis of α-hydroxy phosphonates, a new class of transition state analog inhibitors is described. Methods of incorporating neutral and basic amino acid residues at the N-terminus of α-hydroxy-β-amino dimethyl phosphonate 8 are discuss
