1314357-91-9Relevant academic research and scientific papers
Asymmetric fluoroallylboration of aldehydes
Ramachandran, P. Veeraraghavan,Tafelska-Kaczmarek, Agnieszka,Sakavuyi, Kaumba
supporting information; experimental part, p. 4044 - 4047 (2011/09/20)
Contrary to previous reports, the homologation of benzyloxydifluorovinyllithium with bulky chiral iodomethylboronates readily provides a series of chiral γ,γ-difluoroallylboronates. Asymmetric fluoroallylboration of aldehydes with a 2-phenylbornane-2,3-diol-derived reagent provides gem-difluorinated homoallyl alcohols in good yields and 77-95% ee. Preparation of a chiral α-pyrone in >99% ee has also been described.
