1314406-56-8

Basic information

• Product Name: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene
• Synonyms: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene
• CAS NO: 1314406-56-8
• Molecular Weight: 331.303
• Mol File: 1314406-56-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene(1314406-56-8)
• EPA Substance Registry System: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene(1314406-56-8)

Safety Data

• Hazardous Substances Data: 1314406-56-8(Hazardous Substances Data)

Upstream product

• 73895-87-1 5-amino-2-ethoxycarbonylaminonitrobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 57399-97-0 N-(4-aminophenyl)carbamic acid ethyl ester 
• 150812-24-1 2-ethoxycarbonylamino-5-phthalimidonitrobenzene 
• 721943-05-1 1-ethoxycarbonylamino-4-phthalimidobenzene 

Downstream Products

• 150812-23-0 2-ethoxycarbonylamino-5-(4-fluorobenzylamino)nitrobenzene 
• 150812-12-7 Retigabine 
• 150812-13-8 retigabine dihydrochloride 

Relevant articles and documents

Of retigabine and wherein the intermediate preparation method (by machine translation)

The invention relates to the medicine synthesis field and in particular relates to a preparation method of retigabine and an intermediate thereof. The method specifically comprises the following steps of: (1) preparing a compound with a structure of formula (RET25) by the compound with the structure of formula (RET20) and 4-fluorobenzaldehyde under the action of p-toluene sulfonic acid; (2) preparing the compound with the structure of formula (RET30) by the compound with the structure of formula (RET25) through sodium borohydride reduction; and (3) preparing the retigabine by the compound with the structure of the formula (RET30) through raney nickel hydrogenation reduction. The total impurity content of the retigabine obtained by the preparation method disclosed by the invention is less than 0.16% in terms of area percentage unit of HPLC (High Performance Liquid Chromatography).