131444-89-8

Upstream product

• 186581-53-3 diazomethane 
• 271245-12-6 methyl O-(methyl 4,5:7,8-di-O-isopropylidene-3-O-thiobenzoyl-α-D-glycero-D-talo-2-octulopyranosonate)-(2->6)-2,3,4-tri-O-benzyl-α-D-glucopyranoside 
• 53008-65-4 methyl 2,3,4-tri-O-benzyl-D-glucopyranoside 
• 137945-87-0 (methyl 2,3,4-tri-O-benzyl-α-D-glucopyranosid-6-yl) 2-deoxy-3,4:6,7-di-O-isopropylidene-5-O-<<(trimethylsilyl)ethoxy>methyl>-D-manno-heptonate 
• 137964-64-8 1,3-dideoxy-4,5:7,8-di-O-isopropylidene-2-O-(methyl 2,3,4-tri-O-benzyl-α-D-glucopyranosid-6-yl)-6-O-<<(trimethylsilyl)ethoxy>methyl>-D-manno-oct-1-enitol 
• 137945-81-4 2-deoxy-3,4:6,7-di-O-isopropylidene-5-O-<<(trimethylsilyl)ethoxy>methyl>-D-manno-heptonic acid 
• 137945-78-9 1,2-dideoxy-3,4:6,7-di-O-isopropylidene-5-O-<<(trimethylsilyl)ethoxy>methyl>-D-manno-hept-1-enitol 
• 137945-79-0 2-deoxy-3,4:6,7-di-O-isopropylidene-5-O-<<(trimethylsilyl)ethoxy>methyl>-D-manno-heptitol 
• 137945-76-7 (R)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl][(4S,5R)-5-ethenyl-2,2-dimethyl-1,3-dioxolan-4-yl]methanol 
• 131456-52-5 (methyl 2,3,4-tri-O-benzyl-α-D-glucopyranosid-6-yl) 2-deoxy-3,4:6,7-di-O-isopropylidene-5-O-pivaloyl-D-manno-heptonate 
• 131444-84-3 1,3-dideoxy-4,5:7,8-di-O-isopropylidene-2-O-(methyl 2,3,4-tri-O-benzyl-α-D-glucopyranosid-6-yl)-6-O-pivaloyl-D-manno-oct-1-enitol 
• 131444-88-7 methyl (1-O-acetyl-3-deoxy-4,5:7,8-di-O-isopropylidene-α-D-manno-octulopyranosyl)-(2->6)-(2,3,4-tri-O-benzyl-α-D-glucopyranoside) 
• 137945-88-1 methyl (3-deoxy-4,5:7,8-di-O-isopropylidene-α-D-manno-octulopyranosyl)-(2->6)-(2,3,4-tri-O-benzyl-α-D-glucopyranoside) 
• 131444-86-5 methyl (1,3-dideoxy-1-iodo-4,5:7,8-di-O-isopropylidene-α-D-manno-octulopyranosyl)-(2->6)-(2,3,4-tri-O-benzyl-α-D-glucopyranoside) 

Downstream Products

• 131444-90-1 methyl (methyl 3-deoxy-α-D-manno-octulosonate)-(2->6)-(2,3,4-tri-O-benzyl-α-D-glucopyranoside) 

Relevant academic research and scientific papers

Synthesis of 3-deoxy-D-manno-2-octulosonic acid (Kdo) and D-glycero-D-talo-2-octulosonic acid (Ko) and their α-glycosides

Reaction of 2,3:5,6-di-O-isopropylidene-D-mannofuranose 1 with C-2 lithio derivatives of glyoxylate mercaptal in the presence of MgBr2 afforded D-glycero-D-galacto-2-octulosonates 2 and 3, respectively. Their 3-O-deoxygenation led to Kdo. N-Iod

Cyclization of Hydroxy Enol Ethers: A Stereocontrolled Approach to 3-Deoxy-D-manno-2-octulosonic Acid Containing Disaccharides

A method for the preparation of the carboxylic acids 14 and 15 has been developed, starting from known 2,3,5,6-di-O-isopropylidene-D-mannofuranose.Esterification of 14 and 15 with methanol, methyl 2,3,4-tri-O-benzyl-α-D-glucopyranoside, and 1,2,5,6-di-O-i

A STEREOCONTROLLED APPROACH TO 3-DEOXY-D-MANNO-2-OCTULOSONIC ACID CONTAINING DISACCHARIDES

The development of a synthetic approach to KDO containing disaccharides based on stereocontrolled iodocyclization of an enol ether is detailed.