13145-54-5Relevant academic research and scientific papers
Uranyl-catalyzed hydrosilylation ofpara-quinone methides: access to diarylmethane derivatives
Yu, Jipan,Chen, Siyu,Liu, Kang,Yuan, Liyong,Mei, Lei,Chai, Zhifang,Shi, Weiqun
, p. 1575 - 1579 (2021)
An efficient and convenient uranyl-catalyzed reductive hydrosilylation reaction ofpara-quinone methides (p-QMs) was developed by employing silane as the reductant. The hydrosilylation procedure using the UO2(NO3)2·6H2
B(C6F5)3 catalysed reduction of: Para -quinone methides and fuchsones to access unsymmetrical diaryl- and triarylmethanes: Elaboration to beclobrate
Mahesh, Sriram,Vijaya Anand, Ramasamy
, p. 8393 - 8401 (2017/10/19)
A mild and efficient method for the synthesis of unsymmetrical diaryl- and triarylmethanes through a B(C6F5)3 catalyzed reduction of para-quinone methides and fuchsones respectively, using the Hantzsch ester as a reducing source has been developed. Detailed mechanistic investigations revealed that the reaction actually proceeds through a Lewis acid-base pair complex derived from B(C6F5)3 and the Hantzsch ester.
Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents
Kumbhare, Ravindra M.,Dadmal, Tulshiram,Kosurkar, Umesh,Sridhar,Rao, J. Venkateswara
supporting information; experimental part, p. 453 - 455 (2012/02/16)
Benzothiazolyl thiocarbamides has been achieved using a catalytic amount of 4-dimethylaminopyridine (DMAP) followed by its chemoselective oxidative cyclization with 1,3-di-n-butylimidazolium tribromide[bbim][Br3] to afford the N-bis-benzothiazole derivatives. All the synthesized compounds were evaluated for cytotoxic activity against two human monocytic cell lines (U 937, THP-1) and a mouse melanoma cell line (B16-F10). Based on their IC50 values, the majority of the benzothiazolyl thiocarbamides and N-bis-benzothiazoles had significant antiproliferative activity on U 937 and B16-F10 cells, the compounds 3b, 3e, 3f, 3k, 6c and 6h were found to be the most active. The present findings indicate clearly that the compound 3e exhibited more antiproliferative activity on U 937 cells than the standard molecule, etoposide. Nevertheless, these compounds have shown comparatively less cytotoxicity towards THP-1 cells.
1,3-Di-n-butylimidazolium tribromide-mediated chemoselective oxidative cyclization of benzothiazoyl carbaimides: A novel approach toward the synthesis of N-bis-benzothiazole derivatives
Kumbhare, Ravindra M.,Dadmal, Tulshiram,Kosurkar, Umesh,Vijay Kumar
experimental part, p. 342 - 348 (2012/06/15)
4-(N,N-Dimethylamino)pyridine is found to be an efficient catalyst for the synthesis of benzothiazoyl carbaimide derivatives using 2-aminobenzothiazoles and phenylisothiocyanates, which on treatment with ionic liquid [bbim][Br 3] at 70°C afforded exclusive formation of N-bis-benzothiazole derivatives in good yield. Copyright
Electroorganic Reactions. 31. Quinonemethide Radical-Anions and Dianoins: Their Cathodic Generation and Reactivity
Goulart, Marilia O. F.,Utley, James H. P.
, p. 2520 - 2525 (2007/10/02)
The cathodic reactions of a number of relatively stable quinonemethides have been examined in detail by cyclic voltammetry, controlled potential coulometry, and rigorous product analysis following preparative-scale electrolyses.The results of cyclic voltammetric experiments differ in some respects from those of earlier polarographic work.The lifetimes of the electrogenerated radical-anions and dianions, in the absence of added electrophile, are governed by steric hindrance.Hindered intermediates are relatively long-lived yet hydrogenate in the presence of proton donor and alkylate in the presence of methyl iodide.Less hindered analogue efficiently and rapidly dimerize, at carbon, with concomitant protonation or O-methylation depending on added electrophile.The ambident cathodically generated nucleophiles alkylate at both carbon and oxygen, and the competition is crucially dependent on the cation (Bu4N+ or Li+).Fuchsone 3 gives reduction products which vary with initial concentration and on the presence, or otherwise, of oxygen.Efficient reaction between oxygen and triarylmethyl radicals generated, e.g., from 3 has been demonstrated.
ELECTRO-ORGANIC REACTIONS. PART 32. ELECTROGENERATED BASES FROM QUINONEMETHIDES
Goulart, Marilia O. F.,Ling-Chung Sim K.,Utley, James H. P.
, p. 6081 - 6084 (2007/10/02)
The radical-anion of fuchsone (1), and the dianions of related quinonemethides, are generated at low cathodic potentials and act as bases in high yielding Wittig reactions; the phenolic product may be oxidatively reconverted into quinonemethide.
