1314596-01-4Relevant academic research and scientific papers
A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4- b ]indoles
Medeiros, Matthew R.,Schaus, Scott E.,Porco, John A.
, p. 4012 - 4015 (2011/10/02)
The synthesis of pyrano[3,4-b]indoles is described. The reaction sequence involves Sonogashira coupling of dihydropyran propargyl ether scaffolds with iodoanilines to afford intermediate indoles. Lewis acid-catalyzed ionization of the dihydropyrans, followed by intramolecular C3 alkylation of the indole, provides the title compounds.
