1314696-21-3

Basic information

• Product Name: 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine
• Synonyms: 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine
• CAS NO: 1314696-21-3
• Molecular Weight: 354.489
• Mol File: 1314696-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine(1314696-21-3)
• EPA Substance Registry System: 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine(1314696-21-3)

Safety Data

• Hazardous Substances Data: 1314696-21-3(Hazardous Substances Data)

Upstream product

• 201039-14-7 (R)-2-[2-(4-methyl-piperidine-1-yl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 61350-65-0 (R)-2-(pyrrolidin-2-yl)acetic acid 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 201039-15-8 (R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine 
• 1314696-16-6 tert-butyl (2R)-2-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]pyrrolidine-1-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers

Brain serotonin 7 receptor (5-HT7) is involved in several mood disorders and drug candidates targeting this subtype are currently in development. Positron emission tomography (PET) is a molecular imaging modality offering great promise for accelerating the process from preclinical discovery to clinical phases. As no PET radiopharmaceutical has yet been used successfully to study the 5-HT7 receptor in vivo, our objective is to develop the first 5-HT7 fluorine-18 labeled radiotracer. Four structural analogs of SB269970, a specific 5-HT7 receptor antagonist, divided in FP3 series and FPMP series were synthesized. Their antagonist effects were investigated by cellular functional assay. Nitro-precursors of these analogs were radiolabeled via a [18F-]nucleophilic substitution and in vitro autoradiographies were performed in rat brain. Chemical and radiochemical purities of fluorine radiotracers were >99% with specific activities in 40-129 GBq/μmole range. The four derivates presented antagonism potencies toward 5-HT7 receptors (pKB) between 7.8 and 8.8. The four PET radiotracers had suitable characteristic for 5-HT7 receptor probing in vitro even if the FP3 series seemed to be more specific for this receptor. These results encourage us to pursue in vivo studies.