61350-65-0

Basic information

• Product Name: (2R)-2-Pyrrolidineacetic acid
• Synonyms: (2R)-2-Pyrrolidineacetic acid;(R)-2-(Pyrrolidin-2-yl)acetic acid;(R)-Pyrrolidin-2-yl-acetic acid;D-beta-homoproline
• CAS NO: 61350-65-0
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 61350-65-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2R)-2-Pyrrolidineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-Pyrrolidineacetic acid(61350-65-0)
• EPA Substance Registry System: (2R)-2-Pyrrolidineacetic acid(61350-65-0)

Safety Data

• Hazardous Substances Data: 61350-65-0(Hazardous Substances Data)

Usage

Uses

(R)-2-Pyrrolidineacetic Acid is used as a starting material in the synthetic preparation of GABA uptake and transport inhibitors.

Upstream product

• 201039-13-6 (R)-2-cyanomethyl pyrrolidine-1-carboxylic acid, tert-butyl ester 
• 61350-64-9 (R)-2-{1-[(benzyloxy)carbonyl]pyrrolidin-2-yl}acetic acid 
• 121378-46-9 1-<(R)-1-((S)-3-Phenyllactoyl)-2-pyrrolidinyl>-3,3-dimethyl-2-butanon 
• 121378-48-1 <(S)-1-Benzyl-2-<(R)-2-(3,3-dimethyl-2-oxobutyl)-pyrrolodino>-2-oxoethyl>-2,2-dimethylpropionat 
• 121378-50-5 N-<(S)-3-Phenyl-2-(2,2-dimethylpropionyloxy)-propionyl>-(R)-pyrrolidin-2-ylessigsaeure 

Downstream Products

• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1314696-17-7 tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl)pyrrolidine-1-carboxylate 
• 1314696-19-9 tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl)pyrrolidine-1-carboxylate 
• 1314696-20-2 1-(2-((2R)-1-[(4-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine 
• 1314696-21-3 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine 
• 1314696-23-5 4-methyl-1-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine 
• 1314696-26-8 4-methyl-1-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperidine 
• 1314696-28-0 1-(2-((2R)-1-[(4-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine 
• 1314696-32-6 1-(2-((2R)-1-[(2-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine 
• 1314696-33-7 1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine 
• 1314696-35-9 1-(2-methoxyphenyl)-4-(2-((2R)-1-[(2-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine 
• 1314696-36-0 1-(2-((2R)-1-[(4-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine 
• 1314696-37-1 1-(2-((2R)-1-[(2-[⁽¹⁸⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-methylpiperidine 
• 1314696-40-6 1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine 

Relevant articles and documents

Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers

Brain serotonin 7 receptor (5-HT7) is involved in several mood disorders and drug candidates targeting this subtype are currently in development. Positron emission tomography (PET) is a molecular imaging modality offering great promise for accelerating the process from preclinical discovery to clinical phases. As no PET radiopharmaceutical has yet been used successfully to study the 5-HT7 receptor in vivo, our objective is to develop the first 5-HT7 fluorine-18 labeled radiotracer. Four structural analogs of SB269970, a specific 5-HT7 receptor antagonist, divided in FP3 series and FPMP series were synthesized. Their antagonist effects were investigated by cellular functional assay. Nitro-precursors of these analogs were radiolabeled via a [18F-]nucleophilic substitution and in vitro autoradiographies were performed in rat brain. Chemical and radiochemical purities of fluorine radiotracers were >99% with specific activities in 40-129 GBq/μmole range. The four derivates presented antagonism potencies toward 5-HT7 receptors (pKB) between 7.8 and 8.8. The four PET radiotracers had suitable characteristic for 5-HT7 receptor probing in vitro even if the FP3 series seemed to be more specific for this receptor. These results encourage us to pursue in vivo studies.

Asymetric Electrophilic α-Amidoalkylation 4: Generation and Trapping Reactions of Chiral N-Acylpyrrolidiniumions

The pyrrole derivatives 1, 6, and 10 react in the presence of TiCl4 with the silyl enol ether 3 to form α-substituted pyrrolidine amides stereoselectively. 6 and 10 (after HCl-addition =>11) react even at -78 deg C, the reaction of 10 exceeds that of 6 in yield and stereoselctivity.