1314734-59-2

Basic information

• Product Name: 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde
• Synonyms: 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde
• CAS NO: 1314734-59-2
• Molecular Formula: C12H12BrN3O2
• Molecular Weight: 310.14658
• Mol File: 1314734-59-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 463.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.75±0.1 g/cm3(Predicted)
• PKA: -0.92±0.30(Predicted)
• CAS DataBase Reference: 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde(1314734-59-2)
• EPA Substance Registry System: 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde(1314734-59-2)

Safety Data

• Hazardous Substances Data: 1314734-59-2(Hazardous Substances Data)

Usage

General Description

5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde is a chemical compound with a complex structure. It contains a pyrazolo[3,4-b]pyridine ring system with a bromine atom at the 5th position, a tetrahydro-2H-pyran-2-yl group attached to the 1st position, and a carbaldehyde group at the 3rd position. 5-broMo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde has potential applications in medicinal chemistry and drug discovery due to its unique structure and potential biological activity. It may be used as a building block or intermediate in the synthesis of pharmaceutical compounds or as a research tool in the study of biological pathways and drug targets. Further research and development of this compound may lead to new drug candidates for various therapeutic indications.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 916326-37-9 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde 
• 766-11-0 5-bromo-2-fluoropyridine 
• 885223-65-4 5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine 
• 1314734-58-1 5-bromo-N-methoxy-N-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide 
• 1314734-57-0 5-bromo-N-methoxy-N-methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxamide 
• 916325-85-4 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 
• 916325-84-3 methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate 
• 916325-83-2 pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester 
• 116855-08-4 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 
• 131674-39-0 2-chloro-3-(1-hydroxyethyl)pyridine 
• 116834-96-9 3-methyl-1H-pyrazolo[3,4b]pyridine 
• 109-09-1 2-chloropyridine 
• 55676-21-6 3-acetyl-2-chloropyridine 

Downstream Products

• 1314734-68-3 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde 

Relevant articles and documents

Synthetic method of 3-formyl-1H-pyrazolo [3, 4-b] pyridine-5-carboxylic acid methyl ester

The invention discloses a synthetic method of 3-formyl-1H-pyrazolo [3, 4-b] pyridine-5-carboxylic acid methyl ester. The method comprises the following steps: by taking 5-bromo-1H-pyrazolo [3, 4-b] pyridine-3-carboxylic acid as a raw material, carrying out condensation to obtain weinreb amide 5-bromo-N-methoxy-N-methyl-1H-pyrazolo [3, 4-b] pyridine-3-carboxamide; carrying out DHP protection to obtain 5-bromo-N-methoxy-N-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo [3, 4-b]pyridine-3-formamide; reducing the weinreb amide by using lithium aluminum hydride to obtain 5-bromine-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo [3, 4-b] pyridine-3-formaldehyde; carrying out carbonyl insertion reaction on 5-bromine-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo [3, 4-b] pyridine-3-formaldehyde to obtain 3-formyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo [3, 4-b] pyridine-5-carboxylic acid methyl ester, and finally, carrying out THP removal protection to obtain the product 3-formyl-1H-pyrazolo [3, 4-b] pyridine-5-carboxylic acid methyl ester. The route is mild in reaction condition, simple in subsequent operation and environment-friendly, the product is prepared with high yield and high purity, and the method is suitable for industrial process amplification.

3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF

Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF

Provided herein are compounds according to Formula (I) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers.