131474-81-2Relevant articles and documents
Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines
Tang, Qiang,Yuan, Meng,Duan, Jiahui,Xu, Keke,Li, Ruxue,Xie, Mengqing,Kong, Shuwen,He, Xinwei,Shang, Yongjia
supporting information, (2022/01/19)
A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.
Reactions of methyl ketones and (hetero)arylcarboxamides with N,N-dimethylacetamide dimethyl acetal. A simple metal-free synthesis of 2,4,6-trisubstituted pyridines
Prek, Benjamin,Groelj, Uro,Kasuni, Marta,Zupani, Silvo,Svete, Jurij,Stanovnik, Branko
, p. 184 - 195 (2015/02/19)
Two metal-free syntheses of 2,4,6-trisubstituted pyridines 10a-m and 16a-j are described. N,N,6-Trimethyl-4-(substituted)pyridin-2-amines 10 were prepared from aryl or heteroaryl methyl ketones which were transformed with N,N-dimethylacetamide dimethyl ac
4-Chromenonyl-1,4-dihydropyridines and their use
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Page/Page column 31, (2010/02/17)
The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis o
NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS
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Page/Page column 148, (2010/11/28)
The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.
The use of K-10/ultrasound in the selective synthesis of unsymmetrical β-enamino ketones
Valduga, Claudete J.,Squizani, Adriana,Braibante, Hugo S.,Braibante, Mara E.F.
, p. 1019 - 1022 (2007/10/03)
p-Phenyl substituted β-enamino ketones 2a-p and cyclic β-enamino ketones 4, 6a-f have been prepared by a selective method by dispersing 1,3- diketones and amines on montmorillonite K-10 under sonication.