1314754-79-4Relevant academic research and scientific papers
Base-catalyzed, three-component coupling of aldehydes, terminal aryl acetylenes, and amines: Application to synthesis of propargylamines
Patil, Sachin S.,Patil, Sachin V.,Bobade, Vivek D.
, p. 1157 - 1159 (2011)
Propargylamines are formed in high yield by three-component coupling reaction of aldehydes, terminal aryl acetylenes, and amines in DMSO in the presence of catalytic tetraalkylammonium hydroxide. This reaction does not require a transition-metal catalyst.
Study on the A3-coupling reaction catalyzed by readily available copper-containing minerals. Synthesis of propargylamines
Milen, Mátyás,Gy?rke, Gábor,Dancsó, András,Volk, Balázs
supporting information, (2020/01/13)
The highly atom efficient three-component reaction of aldehydes, secondary amines and acetylenes to form propargylamines (A3-coupling) has been studied with twelve readily available copper-containing minerals. It was found that the reaction could easily be performed in the presence of malachite, brochantite, chrysocolla and azurite in toluene at reflux. The desired products were obtained in good to excellent yields.
