131479-91-9Relevant academic research and scientific papers
Fluorinated matrix metalloproteinases inhibitors - Phosphonate based potential probes for positron emission tomography
Beutel, Bernd,Daniliuc, Constantin G.,Riemann, Burkhard,Sch?fers, Michael,Haufe, Günter
, p. 902 - 909 (2016)
Fluorine-containing inhibitors of matrix metalloproteinases (MMPs) can serve as lead structures for the development of 18F-labeled radioligands. These compounds might be useful as non-invasive imaging probes to characterize pathologies associated with increased MMP activity. Results with a series of fluorinated analogs of a known biphenyl sulfonamide inhibitor have shown that fluorine can be incorporated into two different positions of the molecular scaffold without significant loss of potency in the nanomolar range. Additionally, the potential of a hitherto unknown fluorinated tertiary sulfonamide as MMP inhibitor has been demonstrated.
Solvent and catalyst free three-component coupling of carbonyl compounds, amines and triethylphosphite; A new synthesis of α-aminophosphonates
Chandrasekhar,Narsihmulu, Ch.,Sultana, S. Shameem,Saritha,Prakash, S. Jaya
, p. 505 - 506 (2003)
The first solvent and catalyst free three-component coupling of carbonyl compounds, amines and triethylphosphite is achieved producing α-aminophosphonates at ambient temperature in very high yields.
General procedure for the synthesis of α-amino phosphonates from aldehydes and ketones using indium(III) chloride as a catalyst
Ranu, Brindaban C.,Hajra, Alakananda,Jana, Umasish
, p. 1141 - 1143 (1999)
(matrix presented) (24 examples) A simple, efficient, and general method has been developed for the synthesis of α-amino phosphonates through a one-pot reaction of aldehydes and ketones with amines in the presence of indium(III) chloride as a catalyst.
Preparation of dialkyl 1-(Alkylamino)alkylphosphonates, alkyl [1-(Alkylamino)alkyl]phenylphosphinates and [1-(Alkylamino)alkyl] diphenylphosphine oxides via in situ generated iminium ions
Goldeman, Waldemar,Soroka, Miroslaw
experimental part, p. 2437 - 2445 (2010/09/04)
The reaction of trialkyl phosphites, dialkyl phenylphosphonites or alkyl diphenylphosphinites with N-alkylalkanimines in the presence of hydrogen chloride gives dialkyl 1-(alkylamino)alkylphosphonates, alkyl amino)alkyl]phenylphosphinates or [1-(alkylamino)alkyl]diphenylphosphine oxides respectively, via Arbusov-like reaction of iminium salts generated in situ from N-alkylalkanimines. This reaction is an alternative and competitive to known method of preparation based on the addition of H-P compounds to N-alkylalkanimines, because it gives higher yields, no heating is necessary, and the isolation of products is easy. Georg Thieme Verlag Stuttgart · New York.
New α-amino phosphonic acid derivatives of vinblastine: Chemistry and antitumor activity
Lavielle,Hautefaye,Schaeffer,Boutin,Cudennec,Pierre
, p. 1998 - 2003 (2007/10/02)
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O4-deacetyl-VLB azide (5). All of the new products studied w
Synthesis of organophosphorus compounds via silyl esters of phosphorous acids
Afarinkia, Kamyar,Rees, Charles W.,Cadogan, John I. G.
, p. 7175 - 7196 (2007/10/02)
The addition of trimethylsilyloxy phosphorus (III)derivatives generated in situ to imines at room temperature provides a mild selective and high yielding route to α-aminoalkylphosphorate and α-aminoalkylphenylphosphinate esters. Isocyanates and carbodiimides react similarly to give phosphonoureas and phosphonoguarnidines respectively aldehydes and ketones are much less reactive and cyanides are inert.
