131479-91-9Relevant articles and documents
Fluorinated matrix metalloproteinases inhibitors - Phosphonate based potential probes for positron emission tomography
Beutel, Bernd,Daniliuc, Constantin G.,Riemann, Burkhard,Sch?fers, Michael,Haufe, Günter
, p. 902 - 909 (2016)
Fluorine-containing inhibitors of matrix metalloproteinases (MMPs) can serve as lead structures for the development of 18F-labeled radioligands. These compounds might be useful as non-invasive imaging probes to characterize pathologies associated with increased MMP activity. Results with a series of fluorinated analogs of a known biphenyl sulfonamide inhibitor have shown that fluorine can be incorporated into two different positions of the molecular scaffold without significant loss of potency in the nanomolar range. Additionally, the potential of a hitherto unknown fluorinated tertiary sulfonamide as MMP inhibitor has been demonstrated.
General procedure for the synthesis of α-amino phosphonates from aldehydes and ketones using indium(III) chloride as a catalyst
Ranu, Brindaban C.,Hajra, Alakananda,Jana, Umasish
, p. 1141 - 1143 (1999)
(matrix presented) (24 examples) A simple, efficient, and general method has been developed for the synthesis of α-amino phosphonates through a one-pot reaction of aldehydes and ketones with amines in the presence of indium(III) chloride as a catalyst.
New α-amino phosphonic acid derivatives of vinblastine: Chemistry and antitumor activity
Lavielle,Hautefaye,Schaeffer,Boutin,Cudennec,Pierre
, p. 1998 - 2003 (2007/10/02)
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O4-deacetyl-VLB azide (5). All of the new products studied w
