1314801-98-3Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes
Liu, Sensheng,Cui, Peng,Wang, Juan,Zhou, Haifeng,Liu, Qixing,Lv, Jinliang
, p. 264 - 267 (2019/01/10)
A chemoselective 1,2-reduction of cycloalkyl vinyl ketones via asymmetric transfer hydrogenation is described. The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH-NEt3 azeotrope as both a hydrogen source and solvent under mild conditions. A wide range of 1-cycloalkyl chiral allylic alcohols were obtained in good yields and up to 87% ee. It was found that the alkyl group plays an important role in the enantioselectivity.
Structure-based optimization of click-based histone deacetylase inhibitors
Hou, Jingli,Feng, Congran,Li, Zhonghua,Fang, Qinghong,Wang, Huihui,Gu, Guoxian,Shi, Yikang,Liu, Pi,Xu, Feng,Yin, Zheng,Shen, Jie,Wang, Peng
supporting information; experimental part, p. 3190 - 3200 (2011/07/29)
Previously, we reported a click-chemistry based approach to the synthesis of a novel class of histone deacetylase (HDAC) inhibitors [1]. The lead compound NSC746457 was found to be as potent as SAHA (Vorinostat). Further optimization of NSC746457 by using
