1314850-97-9

Basic information

• Product Name: (S)-5-(4-chlorophenyl)pyrrolidin-2-one
• CAS NO: 1314850-97-9
• Molecular Weight: 195.648
• Mol File: 1314850-97-9.mol

Chemical Properties

• CAS DataBase Reference: (S)-5-(4-chlorophenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-(4-chlorophenyl)pyrrolidin-2-one(1314850-97-9)
• EPA Substance Registry System: (S)-5-(4-chlorophenyl)pyrrolidin-2-one(1314850-97-9)

Safety Data

• Hazardous Substances Data: 1314850-97-9(Hazardous Substances Data)

Upstream product

• 1357378-07-4 tert-butyl 4-(4-chlorophenyl)-4-oxobutanoate 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 53503-49-4 ethyl 4-(4-chlorophenyl)-4-oxobutanoate 

Relevant articles and documents

RETRACTED ARTICLE: Site-selective enzymatic C-H amidation for synthesis of diverse lactams

A major challenge in carbon?hydrogen (C?H) bond functionalization is to have the catalyst control precisely where a reaction takes place. In this study, we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C?H amidation reactions and control the site selectivity to divergently construct b-, g-, and d-lactams, completely overruling the inherent reactivities of the C?H bonds. The enzymes, expressed in Escherichia coli cells, accomplish this abiological carbon?nitrogen bond formation via reactive iron-bound carbonyl nitrenes generated from nature-inspired acyl-protected hydroxamate precursors. This transformation is exceptionally efficient (up to 1,020,000 total turnovers) and selective (up to 25:1 regioselectivity and 97%, please refer to compound 2v enantiomeric excess), and can be performed easily on preparative scale.

Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters

Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification. This strategy is capable of constructing enantioenriched lactams and benzo-lactams of a five-, six-, or seven-membered ring in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodology.

Synthesis of γ-, δ-, and ε-lactams by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters

Highly enantiomerically enriched γ- and δ-lactams have been prepared by a simple and very efficient procedure that involves the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters followed by desulfinylation of the nitrogen atom and spo