1314865-15-0Relevant academic research and scientific papers
Access to antigens related to anthrose using pivotal cyclic sulfite/sulfate intermediates
Milhomme, Ophelie,John, Cedric,Djedaini-Pilard, Florence,Grandjean, Cyrille
, p. 5985 - 5998 (2011/09/16)
Anthrose is the upstream terminal unit of the tetrasaccharide side chain from a major glycoprotein of Bacillus anthracis exosporium and is part of important antigenic determinants. A novel entry to anthrose-containing antigens and precursors is described. The synthetic route, starting from d(+)-fucose, makes use of intermediates featuring a cyclic sulfite or sulfate function which serves successively as a protecting and a leaving group.
