131489-97-9Relevant academic research and scientific papers
Enantiomerically Pure Acetals in Organic Synthesis. 2. Diastereoselective Alkylation of Enantiomeric Lithio Alkyl Lactyl Tetrahydropyranosides and Related Enolates
Mash, Eugene A.,Fryling, James A.
, p. 1094 - 1098 (1991)
A concise approach for the rapid synthesis of enantiomerically pure α-alkylated derivatives of lactate esters and of other enantiomerically pure α-hydroxy esters is presented.This methodology, which makes use of enantiomeric lithium enolates prepared from diastereomeric tetrahydropyranyl ethers derived from alkyl lactates and other α-hydroxy esters, is used to prepare both enantiomers of frontalin from (S)-(-)-methyl lactate.
