1314933-40-8Relevant academic research and scientific papers
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor
Ogasawara, Daisuke,Suzuki, Takayoshi,Mino, Koshiki,Ueda, Rie,Khan, Mohammed Naseer Ahmed,Matsubara, Takuya,Koseki, Koichi,Hasegawa, Makoto,Sasaki, Ryuzo,Nakagawa, Hidehiko,Mizukami, Tamio,Miyata, Naoki
, p. 3702 - 3708 (2011/08/02)
Optically active (1S,2R)-NCL-1 and (1R,2S)-NCL-1 were synthesized and evaluated for their lysine-specific demethylase 1 inhibitory activity and cell growth inhibitory activity. In enzyme assays, the (1S,2R)-isomer was approximately four times more potent than the (1R,2S)-isomer. In cell growth inhibition assays, the two isomers showed similar activity in HEK293 cells and SH-SY5Y cells, whereas the (1S,2R)-isomer showed approximately four times more potent activity than the (1R,2S)-isomer in HeLa cells.
