1314975-89-7Relevant academic research and scientific papers
A solvent and transition metal-free, highly efficient Br?nsted acidic ionic liquid promoted one-potthree-component reactions for the synthesis of tetrasubstituted pyrroles
Balu Atar, Amol,Han, Eunbi,Sohn, Dae Hyup,Kang, Jongmin
, p. 1181 - 1192 (2019)
The present protocol describes a highly efficient, transition metal and solvent-free one-pot annulation of amines, dialkyl acetylenedicarboxylates and β-nitrostyrene using imidazolium Br?nsted acidic ionic liquid for the synthesis of tetrasubstituted pyrroles. A diverse functionalized tetrasubstituted pyrroles derivatives were obtained with excellent yields under transition metal and solvent-free conditions. The Br?nsted acidic ionic liquid can be easily recovered and reused for the next reaction without any effects on the yields of the products. This green protocol provides structurally complex, medicinally important tetrasubstituted pyrroles with various substitution patterns in a one-pot operation.
An efficient one-pot synthesis of tetra-substituted pyrroles
Ghabraie, Elmira,Balalaie, Saeed,Bararjanian, Morteza,Bijanzadeh, Hamid Reza,Rominger, Frank
experimental part, p. 5415 - 5420 (2011/08/06)
The three-component reaction of primary amines, dialkyl acetylenedicarboxylates and β-nitrostyrene derivatives in the presence of Iron(III) chloride afforded 1,2,3,4-tetra-substituted pyrroles in high yields. These reactions could precede via domino Micha
