1315060-45-7

Basic information

• Product Name: 3-[2-(2,4-dimethoxyphenyl)ethyl]-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[4,3-a]isoquinoline-1-carbonitrile hydrochloride
• CAS NO: 1315060-45-7
• Molecular Weight: 471.984
• Mol File: 1315060-45-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[2-(2,4-dimethoxyphenyl)ethyl]-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[4,3-a]isoquinoline-1-carbonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(2,4-dimethoxyphenyl)ethyl]-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[4,3-a]isoquinoline-1-carbonitrile hydrochloride(1315060-45-7)
• EPA Substance Registry System: 3-[2-(2,4-dimethoxyphenyl)ethyl]-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[4,3-a]isoquinoline-1-carbonitrile hydrochloride(1315060-45-7)

Safety Data

• Hazardous Substances Data: 1315060-45-7(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 98841-65-7 2-cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 50-00-0 formaldehyd 
• 43052-77-3 (3,4-dihydro-6,7-dimethoxyisoquinolin-1-yl)acetonitrile 
• 15806-29-8 2,4-dimethoxyphenethylamine 

Relevant articles and documents

6,7-Dimethoxy-3,4-dihydroisoquinolin-1(2H)-ylidenoacetonitrile in some fusion reactions

6,7-Dimethoxy-3,4-dihydroisoquinolin-1-ylacetonitrile in the enamine form readily reacts with acyl iso(thio)cyanates affording in high yields 1,2-fused oxo- and thioxodihydropyrimidoisoquinolines and thiouracyloisoquinolines. The reaction of the enamine with primary amines of diverse classes in the presence of 2 equiv of formaldehyde resulted in 1,2-fused N-substituted tetrahydropyrimidinoisoquinolines whose yields depended on the basicity and sterical accessibility of the reagent. Fused 5-hydroxyindolo-, dioxopyrrolo-, pyrroloisoquinolines formed in medium yields in the one-stage reactions of the enamine with p-benzoquinone, oxalyl chloride, and β-nitrostyrene respectively. The reaction of 1-cyanomethyl-6,7-dimethoxydihydroisoquinoline with acrylonitrile leads to the formation of 1,2-fused iminopyridinoisoquinoline easily hydrolysable to pyridine derivative and readily reacting by the amidine group with aroyl chlorides and arylsulfonyl chlorides. Pleiades Publishing, Ltd., 2011.