43052-77-3

Basic information

• Product Name: (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile
• CAS NO: 43052-77-3
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.2625
• Mol File: 43052-77-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 387.9°C at 760 mmHg
• Flash Point: 188.4°C
• Density: 1.16g/cm³
• Vapor Pressure: 3.18E-06mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile(43052-77-3)
• EPA Substance Registry System: (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile(43052-77-3)

Safety Data

• Hazardous Substances Data: 43052-77-3(Hazardous Substances Data)

Usage

General Description

(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile is a chemical compound with a complex molecular structure. It is a derivative of isoquinoline, a nitrogen-containing heterocyclic compound. The presence of acetonitrile in its structure suggests that it contains a nitrile functional group, which makes it a versatile building block for organic synthesis. The dimethoxy groups indicate the presence of two methoxy (CH3O) functional groups, which can affect its solubility and chemical reactivity. Overall, this compound has potential applications in pharmaceutical and chemical research due to its unique structure and potential reactivity.

Upstream product

• 151-50-8 potassium cyanide 
• 52210-49-8 1-chloromethyl-6,7-dimethoxy-3,4-dihydroisoquinoline hydrogen chloride 
• 52244-06-1 2‐(6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)acetonitrile 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 98841-65-7 2-cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 

Downstream Products

• 1053176-25-2 Br^(1-)*C₂₁H₂₁N₂O₃⁽¹⁺⁾ 
• 1053176-26-3 Br^(1-)*C₂₁H₂₀BrN₂O₃⁽¹⁺⁾ 
• 500264-39-1 4-Amino-9,10-dimethoxy-2-phenyl-6,7-dihydro-2H-pyrido[2,1-a]isoquinoline-1,3-dicarbonitrile 

Relevant articles and documents

6,7-Dimethoxy-3,4-dihydroisoquinolin-1(2H)-ylidenoacetonitrile in some fusion reactions

6,7-Dimethoxy-3,4-dihydroisoquinolin-1-ylacetonitrile in the enamine form readily reacts with acyl iso(thio)cyanates affording in high yields 1,2-fused oxo- and thioxodihydropyrimidoisoquinolines and thiouracyloisoquinolines. The reaction of the enamine with primary amines of diverse classes in the presence of 2 equiv of formaldehyde resulted in 1,2-fused N-substituted tetrahydropyrimidinoisoquinolines whose yields depended on the basicity and sterical accessibility of the reagent. Fused 5-hydroxyindolo-, dioxopyrrolo-, pyrroloisoquinolines formed in medium yields in the one-stage reactions of the enamine with p-benzoquinone, oxalyl chloride, and β-nitrostyrene respectively. The reaction of 1-cyanomethyl-6,7-dimethoxydihydroisoquinoline with acrylonitrile leads to the formation of 1,2-fused iminopyridinoisoquinoline easily hydrolysable to pyridine derivative and readily reacting by the amidine group with aroyl chlorides and arylsulfonyl chlorides. Pleiades Publishing, Ltd., 2011.