1315128-48-3

Upstream product

• 158851-29-7 (+)-tert-butyl [(1R)-1-phenylprop-2-en-1-yl]imidocarbonate 
• 85217-69-2 cinnamyl methyl carbonate 
• 1234693-00-5 (+)-tert-butyl formyl[(1R)-1-phenylprop-2-en-1-yl]carbamate 
• 913344-40-8 tert-butyl N-formyl carbamate 
• 31930-36-6 ethyl (Z)-3-iodopropenoate 

Downstream Products

• 1315128-91-6 (-)-tert-butyl (2R,5R)-2-(2-ethoxy-2-oxoethyl)-5-phenylpyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Enantioselective syntheses of 2,5-disubstituted pyrrolidines based on iridium-catalyzed allylic aminations-total syntheses of alkaloids from amphibian skins

A broadly applicable route to trans-2,5-disubstituted pyrrolidines has been developed. Key steps are an asymmetric iridium-catalyzed allylic amination, a Suzuki-Miyaura coupling, and an intramolecular aza-Michael addition. Enantiomeric excesses in the range of 93-99 % ee have been achieved. Total syntheses of the alkaloids (-)-225 C, (+)- and (-)-223 H (xenovenine), (+)-223 AB, (+)-195 B, and (+)-223 R have been carried out as applications. Copyright