1315258-40-2Relevant academic research and scientific papers
A highly active and selective palladium pincer catalyst for the formation of α-aryl ketones via cross-coupling
Bugarin, Alejandro,Connell, Brian T.
, p. 7218 - 7220 (2011)
Several air and moisture stable Pd(ii) pincer complexes were synthesized via oxidative addition of Pd(0) to novel PheBox pincer ligand precursors. Low loadings (1 mol%) of the Pd complex [t-BuPhebox-Me2]PdBr are capable of efficiently promoting the selective α-monoarylation of a variety of ketones with numerous aryl bromides in only 1 h at 70°C with 82-99% yields.
Ylide-Functionalized Phosphine (YPhos)-Palladium Catalysts: Selective Monoarylation of Alkyl Ketones with Aryl Chlorides
Hu, Xiao-Qiang,Lichte, Dominik,Rodstein, Ilja,Weber, Philip,Seitz, Ann-Katrin,Scherpf, Thorsten,Gessner, Viktoria H.,Goo?en, Lukas J.
supporting information, p. 7558 - 7562 (2019/10/02)
Ylide-functionalized phosphine (YPhos) ligands allow the palladium-catalyzed α-arylation of alkyl ketones with aryl chlorides with record setting activity. Using a cyclohexyl-substituted YPhos ligand, a wide range of challenging ketone substrates was efficiently and selectively monoarylated under mild conditions. A newly designed YPhos ligand bearing tert-butyl groups on the coordinating phosphorus atom is already active at room temperature. The synthetic potential was demonstrated by gram-scale reactions and the succinct synthesis of ?-caprolactone derivatives.
