1315306-66-1

Basic information

• Product Name: 3-(4-chlorophenyl)-6'-methoxy-spiro[oxirane-2,3'-thiochroman]-4'-one
• Synonyms: 3-(4-chlorophenyl)-6'-methoxy-spiro[oxirane-2,3'-thiochroman]-4'-one
• CAS NO: 1315306-66-1
• Molecular Weight: 332.807
• Mol File: 1315306-66-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-6'-methoxy-spiro[oxirane-2,3'-thiochroman]-4'-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-6'-methoxy-spiro[oxirane-2,3'-thiochroman]-4'-one(1315306-66-1)
• EPA Substance Registry System: 3-(4-chlorophenyl)-6'-methoxy-spiro[oxirane-2,3'-thiochroman]-4'-one(1315306-66-1)

Safety Data

• Hazardous Substances Data: 1315306-66-1(Hazardous Substances Data)

Upstream product

• 13739-36-1 β-(4-methoxyphenylmercapto)propionic acid 
• 861561-38-8 3-bromo-6-methoxythiochroman-4-one 
• 104-88-1 4-chlorobenzaldehyde 
• 696-63-9 4-Methoxybenzenethiol 
• 13735-11-0 6-methoxy-2,3-dihydro-4H-thiochromen-4-one 

Relevant articles and documents

Design and synthesis of α,β-epoxyketones as new anticancer agents

As epoxy functional group has high anticancer activity, α,β-epoxyketones were designed and synthesized as new anticancer agents, and their structures were confirmed by UV, 1H NMR, IR, MS technigeces and elemental analysis. Their in vitro anticancer activities were evaluated by MTT method and the results showed that the compound 4c exhibited good activity with IC50 of 17.8, 22.0 and 24.1 μg/mL against A-549, Hela and HepG2 cells, respectively. The dose of LD50 of the mice by intragastric administration was 1864.4 mg/kg. Therefore, the α,β-epoxyketones could potentially provide as new anticancer agents. A series of α,β-epoxyketones were synthesized in a four steps reaction and tested for their anticancer activities.