131533-62-5

Basic information

• Product Name: [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid methyl ester
• CAS NO: 131533-62-5
• Molecular Weight: 386.404
• Mol File: 131533-62-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid methyl ester(131533-62-5)
• EPA Substance Registry System: [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid methyl ester(131533-62-5)

Safety Data

• Hazardous Substances Data: 131533-62-5(Hazardous Substances Data)

Upstream product

• 74-83-9 methyl bromide 
• 1068-52-6 sodium 2-bromoacetate 
• 124831-36-3 N-[(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide 
• 2065-23-8 methyl 2-phenoxyacetate 
• 130050-07-6 [(2R,3S)-3-Amino-2-(2-furan-2-yl-ethyl)-4-oxo-azetidin-1-yl]-acetic acid methyl ester 
• 110289-29-7 (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one 
• 99333-65-0 1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 

Downstream Products

• 131533-83-0 [(3S,4R)-2-Oxo-3-(2-phenoxy-acetylamino)-4-(2-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid methyl ester 
• 131533-94-3 (6R,7S)-3-Hydroxy-8-oxo-7-(2-phenoxy-acetylamino)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester 
• 138995-64-9 [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 4-methyl-benzyl ester 
• 131533-73-8 3-[(2R,3S)-1-Methoxycarbonylmethyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl]-propionic acid 
• 138995-63-8 [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid benzyl ester 

Relevant articles and documents

ENANTIOSELECTIVE ACYLATION OF A BETA-LACTAM INTERMEDIATE IN THE SYNTHESIS OF LORACARBEF USING PENICILIIN G AMIDASE

Penicillin G amidase from E. coli has been shown to selectively acylate, in an efficient manner, the (2R,3S) isomer of a cis, racemic azetidinone intermediate used in a synthesis of loracarbef, a carbacephalosporin antibiotic.The acylation occurs using methyl phenylacetate (MPA) and using methyl phenoxyacetate (MPOA) as the acylating agents.The enzyme displays similar enantioselectivity with MPOA or MPA.