124831-36-3

Upstream product

• 110289-29-7 (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one 
• 701-99-5 Phenoxyacetyl chloride 
• 99333-65-0 1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 

Downstream Products

• 131533-62-5 [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid methyl ester 
• 131533-60-3 [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 4-methoxy-benzyl ester 
• 131533-61-4 [(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester 
• 123932-46-7 carbacephalosporin hydrochloride 
• 76470-66-1 loracarbef 
• 119892-46-5 p-nitrobenzyl 7β-[(phenoxyacetyl)amino]-3-hydroxy-1-carba-1-dethia-3-cephem-4-carboxylate 
• 119892-48-7 cis-α-diazo-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 
• 124831-39-6 (6R,7S)-3-Chloro-7-[(R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 124831-38-5 cis-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 
• 131533-82-9 [(3S,4R)-2-Oxo-3-(2-phenoxy-acetylamino)-4-(2-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester 
• 131533-81-8 [(3S,4R)-2-Oxo-3-(2-phenoxy-acetylamino)-4-(2-phenylsulfanylcarbonyl-ethyl)-azetidin-1-yl]-acetic acid 4-methoxy-benzyl ester 
• 131533-72-7 3-[(2R,3S)-1-(4-Nitro-benzyloxycarbonylmethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl]-propionic acid 
• 131533-93-2 (6R,7S)-3-Hydroxy-8-oxo-7-(2-phenoxy-acetylamino)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 131533-71-6 3-[(2R,3S)-1-(4-Methoxy-benzyloxycarbonylmethyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl]-propionic acid 

Relevant academic research and scientific papers

Synthesis of carbacephem antibiotics: Synthesis via Dieckmann reaction using phenyl esters to direct the regioselectivity of the cyclization

β-Ketoesters useful for elaboration to carbacephems were synthesized from a variety of enantiomerically pure diesters. Use of phenyl esters to direct the regioselectivity was demonstrated.

AN ENANTIOSELECTIVE SYNTHESIS OF LORACARBEF (LY163892/KT3777)

An enantioselective synthesis of the new, orally absorbable, totally synthetic β-lactam antibiotic, loracarbef(LY163892/KT3777) is described.