1315463-58-1

Basic information

• Product Name: 6-(4-(2-(azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate
• Synonyms: 6-(4-(2-(azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate
• CAS NO: 1315463-58-1
• Molecular Weight: 516.403
• Mol File: 1315463-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-(2-(azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-(2-(azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate(1315463-58-1)
• EPA Substance Registry System: 6-(4-(2-(azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate(1315463-58-1)

Safety Data

• Hazardous Substances Data: 1315463-58-1(Hazardous Substances Data)

Upstream product

• 1315465-13-4 tert-butyl 3-(2-(4-(5-amino-6-cyano-4-(methylamino)pyridin-2-yl)-2-(trifluoromethyl)phenoxy)ethyl)azetidine-1-carboxylate 
• 1315465-12-3 tert-butyl 3-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenoxy)ethyl)azetidine-1-carboxylate 
• 1315465-11-2 tert-butyl 3-(2-(4-bromo-2-(trifluoromethyl)phenoxy)ethyl)azetidine-1-carboxylate 
• 1104380-99-5 3-amino-6-chloro-4-(methylamino)-2-pyridinecarbonitrile 
• 1104380-98-4 6-chloro-4-(methylamino)-3-nitro-2-pyridinecarbonitrile 
• 944388-71-0 4-amino-6-chloro-3-nitropyridine-2-carbonitrile 
• 183062-96-6 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid 
• 152537-03-6 tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate 
• 1315465-14-5 tert-butyl 3-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)azetidine-1-carboxylate 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1315463-60-5 6-(4-(2-(1-(2-dimethylamino-2-oxoethyl)azetidin-3-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride 

Relevant articles and documents

1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES

The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1 -3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn....S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.