1315469-94-3

Upstream product

• 211796-64-4 4-formyl-3-(trifluoromethyl)benzonitrile 
• 211796-64-4 4-dibromo-2-(trifluoromethyl)benzaldehyde 
• 887565-40-4 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 1315466-65-9 4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide 
• 1315381-28-2 4-chloro-N-(5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenyl)-1-tosyl-pyrrolo[2,3-b]pyridine-5-carboxamide 
• 1315322-50-9 N-(3-((5-acetamidopyrazin-2-ylmethyl)amino)-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide 
• 1315380-71-2 tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate 

Relevant academic research and scientific papers

Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties

Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1