N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide
CAS No.:1315469-94-3
Molecular Formula:C₂₂H₂₇F₃N₄O
Molecular Weight:420.478
Hs Code.:

Synonyms:N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

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Chemical Property of N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

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Technology Process of N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

There total 4 articles about N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887565-40-4
4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoic acid

: 1315469-94-3
N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

1.2: 15 h / 20 °C

2.1: iron; ammonium chloride / water; ethanol / 2 h / 100 °C / Sealed tube

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113298

Reference yield:

: 211796-64-4,861928-27-0
4-dibromo-2-(trifluoromethyl)benzaldehyde

: 1315469-94-3
N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / Heating

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C

3.1: sodium hydroxide / water; methanol; tetrahydrofuran / 2.5 h / 100 °C / Sealed tube

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

4.2: 15 h / 20 °C

5.1: iron; ammonium chloride / water; ethanol / 2 h / 100 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113298

Reference yield:

: 211796-64-4
4-formyl-3-(trifluoromethyl)benzonitrile

: 1315469-94-3
N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 20 °C

2.1: sodium hydroxide / water; methanol; tetrahydrofuran / 2.5 h / 100 °C / Sealed tube

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 15 h / 20 °C

4.1: iron; ammonium chloride / water; ethanol / 2 h / 100 °C / Sealed tube

With sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113298