1315478-16-0

Basic information

• Product Name: 2-butyl-1,6-dihydro-4-Methyl-6-oxo-5-PyriMidineacetic acid
• Synonyms: 2-butyl-1,6-dihydro-4-Methyl-6-oxo-5-PyriMidineacetic acid;(2-Butyl-4-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl)acetic acid
• CAS NO: 1315478-16-0
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.25634
• Mol File: 1315478-16-0.mol

Chemical Properties

• Boiling Point: 386.9±44.0 °C(Predicted)
• Appearance: white powders
• Density: 1.24±0.1 g/cm3 (20 oC 760 Torr)
• PKA: 4.00±0.10(Predicted)
• CAS DataBase Reference: 2-butyl-1,6-dihydro-4-Methyl-6-oxo-5-PyriMidineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-1,6-dihydro-4-Methyl-6-oxo-5-PyriMidineacetic acid(1315478-16-0)
• EPA Substance Registry System: 2-butyl-1,6-dihydro-4-Methyl-6-oxo-5-PyriMidineacetic acid(1315478-16-0)

Safety Data

• Hazardous Substances Data: 1315478-16-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-butyl-1,6-dihydro-4-methyl-6-oxo-5-Pyrimidineacetic acid is used as a building block in the synthesis of more complex organic compounds. Its multiple reactive sites make it a valuable intermediate in the creation of pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Pharmaceutical Development:
2-butyl-1,6-dihydro-4-methyl-6-oxo-5-Pyrimidineacetic acid is used as a key component in the development of new drugs. Its unique structure and reactivity may contribute to the discovery of novel therapeutic agents with potential applications in various medical fields.
Used in Material Science:
2-butyl-1,6-dihydro-4-methyl-6-oxo-5-Pyrimidineacetic acid is used as a precursor in the synthesis of advanced materials, such as polymers or composites, that could have applications in industries like electronics, automotive, or aerospace.
Used in Research and Development:
2-butyl-1,6-dihydro-4-methyl-6-oxo-5-Pyrimidineacetic acid is used as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to gain insights into new chemical reactions or to develop innovative applications in various fields.

Upstream product

• 10420-33-4 dimethyl 2-acetylsuccinate 
• 18257-46-0 pentanamidine hydrochloride 
• 110-59-8 pentanonitrile 
• 1115-30-6 diethyl acetylsuccinate 

Downstream Products

• 1315478-13-7 (2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide) 
• 247257-48-3 Fimasartan 

Relevant articles and documents

Method for preparing Fimasartan

The invention discloses a method for preparing Fimasartan. The method comprises the steps that valeronitrile is used as a raw material to prepare pentanimidamide hydrochloride, then pentanimidamide hydrochloride and acetylsuccinic acid diethyl ester conduct a cyclization reaction and an amidation reaction to prepare 2-(2-normal-butyl-4-hydroxyl-6-methylpyrimidine-5-radical)-N,N-dimethylacetamide (intermediate II), the intermediate II is subjected to sulfo-carbonylation through a Lawesson's reagent to obtain 2-(2-normal-butyl-4-hydroxyl-6-methylpyrimidine-5-radical)-N,N-dimethylacetamide (intermediate III), the intermediate III is subjected to an N-alkylation reaction, radicals are protected through detritylation, and Fimasartan is prepared. The preparation method has the advantages of highreaction selectivity, high synthesis yield, high reaction efficiency and the like.

NOVEL PREPARATION METHOD OF 2-(2-N-BUTYL-4-HYDROXY-6-METHYL-PYRIMIDIN-5-YL)-N,N-DIMETHYLACETAMIDE

The present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising reacting a compound of the following formula 2 with pentanamidine or a salt thereof in the presence of a base. [Formula 2] wherein R1 represents C1-C6 linear or branched alkyl or C3-C6 cycloalkyl. Further, the present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising the steps of: a) reacting 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-acetic acid with a haloformate compound in the presence of a base, and b) reacting the product of Step a) with dimethylamine.