1315511-53-5

Basic information

• Product Name: 3,4-dinitro-N-(2-propyn-1-yl)benzamide
• Synonyms: 3,4-dinitro-N-(2-propyn-1-yl)benzamide
• CAS NO: 1315511-53-5
• Molecular Weight: 249.183
• Mol File: 1315511-53-5.mol

Chemical Properties

• CAS DataBase Reference: 3,4-dinitro-N-(2-propyn-1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dinitro-N-(2-propyn-1-yl)benzamide(1315511-53-5)
• EPA Substance Registry System: 3,4-dinitro-N-(2-propyn-1-yl)benzamide(1315511-53-5)

Safety Data

• Hazardous Substances Data: 1315511-53-5(Hazardous Substances Data)

Upstream product

• 528-45-0 3,4-dinitrobenzoic acid 
• 2450-71-7 Propargylamine 

Downstream Products

• 1249131-20-1 C₉H₆FN₃O₃ 
• 1096823-60-7 4-[19]fluoro-3-nitro-N-(2-propyn-1-yl)benzamide 
• 1392145-41-3 4-[18]fluoro-3-nitro-N-(2-propyn-1-yl)benzamide 
• 1392145-46-8 C₄₁H₆₄⁽¹⁸⁾FN₁₃O₁₁ 
• 1392145-47-9 C₄₇H₇₅⁽¹⁸⁾FN₁₄O₁₂ 

Relevant articles and documents

One-step radiosynthesis of 4-[18F]flouro-3-nitro-N-2-propyn-1- yl-benzamide ([18F]FNPB): A new stable aromatic porosthetic group for efficient labeling of peptides with fluorine-18

4-[18F]flouro-3-nitro-N-2-propyn-1-yl-benzamide ([ 18F]FNPB) was developed as a new stable aromatic prosthetic group for more efficient click labeling of peptides. A new aromatic precursor 3,4-dinitro-N-2-propyn-1-yl-benzamide was radiofluorinated using [ 18F]KF/K2.2.2 followed by HPLC purification to obtain the desired product [18F]FNPB. [18F]FNPB was synthesized with a 58% radiochemical yield, a specific activity > 350 GBq/μmol, and radiochemical purity was exceeded 98% in 40 min. The in vitro stability studies showed no detectable radiodefluorination over 2 h in mouse plasma. The click labeling yield of three different peptides with [18F]FNPB were all above 87%. The in vitro study suggests that [18F]FNPB may be stable in vivo and could have general application in labeling peptides with high radiochemical yield for positron emission tomography applications. Copyright