1315549-67-7Relevant academic research and scientific papers
Efficient enantioselective synthesis of 3-aminochroman derivatives through ruthenium-synphos catalyzed asymmetric hydrogenation
Wu, Zi,Ayad, Tahar,Ratovelomanana-Vidal, Virginie
, p. 3782 - 3785 (2011)
A highly enantioselective asymmetric hydrogenation of various trisubstituted enamides derived from chroman-3-ones promoted by cationic Ru-Synphos catalysts is reported. This atom-economical and clean method provides an efficient route to optically active
Rhodium-Catalyzed Asymmetric Hydrogenation of 3-Benzoylaminocoumarins for the Synthesis of Chiral 3-Amino Dihydrocoumarins
Xu, Yunnan,Liu, Delong,Deng, Yu,Zhou, Yi,Zhang, Wanbin
supporting information, p. 23602 - 23607 (2021/10/05)
An asymmetric hydrogenation of 3-benzoylaminocoumarins was achieved for the first time using our BridgePhos-Rh catalytic system, providing chiral 3-amino dihydrocoumarins in high yields (up to 98 %) and with excellent enantioselectivities (up to 99.7 % ee). The relationship between the enantioselectivities of the hydrogenations and the dihedral angles and the resulting π-π stacking effects of the BridgePhos-Rh complexes, which were determined by X-ray diffraction analysis, are discussed. The corresponding hydrogenated products allow for many transformations, providing several chiral skeletons with important physiological and pharmacological activities.
