2549-08-8Relevant articles and documents
Rhodium-Catalyzed Asymmetric Hydrogenation of 3-Benzoylaminocoumarins for the Synthesis of Chiral 3-Amino Dihydrocoumarins
Xu, Yunnan,Liu, Delong,Deng, Yu,Zhou, Yi,Zhang, Wanbin
supporting information, p. 23602 - 23607 (2021/10/05)
An asymmetric hydrogenation of 3-benzoylaminocoumarins was achieved for the first time using our BridgePhos-Rh catalytic system, providing chiral 3-amino dihydrocoumarins in high yields (up to 98 %) and with excellent enantioselectivities (up to 99.7 % ee). The relationship between the enantioselectivities of the hydrogenations and the dihedral angles and the resulting π-π stacking effects of the BridgePhos-Rh complexes, which were determined by X-ray diffraction analysis, are discussed. The corresponding hydrogenated products allow for many transformations, providing several chiral skeletons with important physiological and pharmacological activities.
Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold
Matos, Maria J.,Vilar, Santiago,Kachler, Sonja,Celeiro, Maria,Vazquez-Rodriguez, Saleta,Santana, Lourdes,Uriarte, Eugenio,Hripcsak, George,Borges, Fernanda,Klotz, Karl-Norbert
, p. 1 - 6 (2015/06/08)
With the aim of finding new adenosine receptor (AR) ligands presenting the 3-amidocoumarin scaffold, a study focusing on the discovery of new chemical entities was carried out. The synthesized compounds 1-8 were evaluated in radioligand binding (A1/
A one-pot [Bmim]OH-mediated synthesis of 3-benzamidocoumarins
Yadav, Lal Dhar S.,Singh, Santosh,Rai, Vijai K.
experimental part, p. 2208 - 2212 (2009/08/07)
The first example of an ionic liquid-promoted one-pot synthesis of 3-benzamidocoumarins from salicylaldehydes and 2-pheny-1,3-oxazolan-5-one via Knoevenagel condensation-ring transformation cascades has been reported. No by-product formation, operational
