131559-05-2Relevant articles and documents
Aza-Henry reactions on C-Alkyl substituted aldimines
Pelagalli, Alessia,Pellacani, Lucio,Scandozza, Elia,Fioravanti, Stefania
, (2016/07/07)
The reactivity of C-CH3 substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF3 aldimines, they gave the aza-Henry addition only when ZrCl4 was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity.
Preparation of tri- and difluoromethylated amines from aldimines using (trifluoromethyl)trimethylsilane
Surya Prakash,Mogi, Ryo,Olah, George A.
, p. 3589 - 3592 (2007/10/03)
Addition of a trifluoromethyl group into aldimines was accomplished using (trifluoromethyl)trimethylsilane with tetraalkylammonium fluorides as initiators, and the resulting adducts were converted to difluoromethylated imines in the presence of excess flu
Early-late, mixed-metal compounds supported by amidophosphine ligands
Mokuolu, Q. Folashade,Duckmanton, Paul A.,Hitchcock, Peter B.,Wilson, Claire,Blake, Alexander J.,Shukla, Lena,Love, Jason B.
, p. 1960 - 1970 (2007/10/03)
A series of discrete early-late mixed-metal compounds supported by amidophosphine ligands were studied. Their sequential synthesis, structure and the reaction profiles were also investigated. X-ray crystal structure analysis and cyclic voltammetry were carried out for the studies. The compounds were found to be inert to transamination and protonolysis reactions with Ti amides and alkyls. The catalyst activity of the complexes were also discussed.
Condensation of laterally lithiated o-methyl and o-ethyl benzamides with imines mediated by (-)-sparteine. Enantioselective synthesis of tetrahydroisoquinolin-1-ones
Derdau,Snieckus
, p. 1992 - 1998 (2007/10/03)
The first asymmetric synthesis of tetrahydroisoquinolin-1-ones using a (-)-sparteine-mediated lateral metalation-imine addition sequence to furnish 3-phenyl tetrahydroisoquinolinones 3a with enantioselectivities up to 81% ee is described (Scheme 4). For amide 7b, imine addition products 10 and 11 have been obtained with high diastereoselectivities (91-97% de) and enantioselectivities (91-98% ee) (Scheme 8).
