13156-23-5

Upstream product

• 5771-13-1 2-methyl-2-hydroxy-2,3-dihydro-1,4-benzodioxin 
• 120-80-9 benzene-1,2-diol 
• 78-95-5 chloroacetone 
• 1219622-14-6 S-adenosyl-S-(propan-2-one)-L-methionine 
• 2164-33-2 2-chloromethyl-1,4-benzodioxane 
• 91933-95-8 2-chloro-2-methyl-1,4-benzodioxan 
• 7732-18-5 water 
• 5770-65-0 2-ethoxy-2-methyl-2,3-dihydro-benzo[1,4]dioxin 
• 7664-93-9 sulfuric acid 
• 3328-78-7 2,3-dihydro-2-methylene-1,4-benzodioxin 

Downstream Products

• 6437-46-3 1-(2-methoxyphenoxy)propan-2-one 
• 65304-43-0 3-(2'-Hydroxyphenoxy)-3-penten-2-on 

Relevant academic research and scientific papers

Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: A tool for the functional analysis of methyltransferases

"Chemical equation presented" S-Adenosylmethionine (AdoMet or SAM)-dependent methyltransferases belong to a large and diverse family of group-transfer enzymes that perform vital biological functions on a host of substrates. Despite the progress in genomics, structural proteomics, and computational biology, functional annotation of methyltransferases remains a challenge. Herein, we report the synthesis and activity of a new AdoMet analogue functionalized with a ketone group. Using catechol O-methyltransferase (COMT, EC 2.1.1.6) and thiopurine S-methyltransferase (TPMT, EC 2.1.1.67) as model enzymes, this robust and readily accessible analogue displays kinetic parameters that are comparable to AdoMet and exhibits multiple turnovers with enzyme. More importantly, this AdoMet surrogate displays the same substrate specificity as the natural methyl donor. Incorporation of the ketone group allows for subsequent modification via bio-orthogonal labeling strategies and sensitive detection of the tagged ketone prod cts. Hence, this AdoMet analogue expands the toolbox available to interrogate the biochemical functions of methyltransferases.

Pyrimidinedione derivatives and antiarrhythmic agents containing same

Pyrimidinedione derivatives of the formula: STR1 wherein R1 and R2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R3, R4, X1, X2 and X3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.

On the Reaction of α-(2-Hydroxyphenoxy)alkylketones with Dimethylsulphoxonium Methylide. A Novel Route to 2-Substituted-2,3-dihydro-2-hydroxymethyl-1,4-benzodioxins

A new route to 2-substituted-2,3-dihydro-2-hydroxymethyl-1,4-benzodioxins 3 based on the reaction of α-(2-hydroxyphenoxy)alkylketones 1 with dimethylsulphoxonium methylide in dimethylsulphoxide is reported.Besides the desired compounds 3, the isomeric 2H-

STRUCTURE OF THE PRODUCTS OF THE O-MONOALKYLATION OF PYROCATECHOL BY α-BROMOKETONES

The reaction of pyrocatechol with α-bromoketones in the presence of triethylamine leads to the formation of o-hydroxyphenoxymethyl ketones or 2-hydroxy-2,3-dihydro-1,4-benzodioxines.PMR spectroscopy revealed ring-chain tautomerism of the products obtained