131565-26-9

Basic information

• Product Name: (S)-methyl 2-((R)-hydroxy(phenyl)methyl)butanoate
• Synonyms: (S)-methyl 2-((R)-hydroxy(phenyl)methyl)butanoate
• CAS NO: 131565-26-9
• Molecular Weight: 208.257
• Mol File: 131565-26-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-((R)-hydroxy(phenyl)methyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-((R)-hydroxy(phenyl)methyl)butanoate(131565-26-9)
• EPA Substance Registry System: (S)-methyl 2-((R)-hydroxy(phenyl)methyl)butanoate(131565-26-9)

Safety Data

• Hazardous Substances Data: 131565-26-9(Hazardous Substances Data)

Upstream product

• 5336-76-5 methyl 2-benzoylbutanoate 
• 186581-53-3 diazomethane 
• 14367-04-5 erythro-2-Ethyl-3-hydroxy-3-phenylpropionsaeure 
• 623-42-7 butanoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 3196-15-4 Methyl 2-bromobutyrate 
• 623-43-8 methyl crotonate 
• 14367-04-5 threo-2-Ethyl-3-hydroxy-3-phenylpropionsaeure 
• 79868-63-6 2-(α-hydroxy-benzyl)-butyric acid methyl ester 
• 55453-12-8 (1-methoxybut-1-enyloxy)trimethylsilane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant articles and documents

Chiral ferrocene P-N-N ligand with high steric hindrance, and preparation method and application thereof

The invention provides a chiral ferrocene P-N-N ligand compound with high steric hindrance, and a preparation method and application thereof, specifically application of the chiral ferrocene P-N-N ligand compound to asymmetric catalytic hydrogenation of beta-keto ester compounds. The preparation method for the chiral ferrocene P-N-N ligand compound with high steric hindrance comprises the following steps: dissolving a chiral ferrocenephosphine-amine compound and a pyridone compound in a reaction solvent; adding active Al2O3 and a dehydrating agent; carrying out a reflux condensation reaction; then carrying out re-dissolving in absolute ethyl alcohol after filtering and desolventizing; adding a palladium/carbon catalyst and carrying out a hydrogenation reaction in an autoclave under a certain reaction pressure; and then successively carrying out filtration, desolventizing and column chromatographic treatment so as to obtain the desired chiral ferrocene P-N-N ligand compound with high steric hindrance. The chiral ferrocene P-N-N ligand compound with high steric hindrance in the invention can be used for asymmetric catalytic hydrogenation of beta-keto ester and can realize high-yield, high-diastereoselectivity high-enantioselectivity preparation of chiral beta-hydroxy ester.

Reductive aldol-type reaction of α,β-unsaturated esters with aldehydes or ketones in the presence of Rh catalyst and Et2Zn

The reaction of RhCl(PPh3)3 with Et2Zn easily generated a rhodium-hydride complex (Rh-H) that added to α,β-unsaturated esters to form rhodium enolate complexes by formal 1,4-reduction. These rhodium enolates gave the corre

Chromium(II)-Mediated Reformatsky Reactions of Carboxylic Esters with Aldehydes

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