131589-45-2Relevant academic research and scientific papers
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
Vega, María Celeste,Rolón, Miriam,Montero-Torres, Alina,Fonseca-Berzal, Cristina,Escario, José Antonio,Gómez-Barrio, Alicia,Gálvez, Jorge,Marrero-Ponce, Yovani,Arán, Vicente J.
supporting information, p. 214 - 227 (2013/02/23)
Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and benznidazole, is far from satisfactory and therefore the development of new antichagasic compounds remains an important goal. On the basis of antichagasic properties previously
Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies
Rodriguez, Jorge,Gerpe, Alejandra,Aguirre, Gabriela,Kemmerling, Ulrike,Piro, Oscar E.,Aran, Vicente J.,Maya, Juan Diego,Olea-Azar, Claudio,Gonzalez, Mercedes,Cerecetto, Hugo
scheme or table, p. 1545 - 1553 (2009/07/04)
New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent (14) affords good activity, b
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity
Bruneau,Delvare,Edwards,McMillan
, p. 1028 - 1036 (2007/10/02)
Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and cyclooxygenase (CO) involve a redox cycle, a compound which reduces 5-LPO and CO to their inactive state would give a nonselective inhi
