13159-99-4

Basic information

• Product Name: N-[4-(DIMETHYLAMINO)BENZYL]-N-(4-METHOXYPHENYL)AMINE
• Synonyms: N4,N4-DIMETHYL-N-ALPHA-(PARA-METHOXYPHENYL)-ALPHA,4-TOLUENEDIAMINE;N-[(4-diMethylaMinophenyl)Methyl]-4-Methoxy-aniline;4-[(4-methoxyanilino)methyl]-N,N-dimethylaniline
• CAS NO: 13159-99-4
• Molecular Formula: C₁₆H₂₀N₂O
• Molecular Weight: 256.34
• Mol File: 13159-99-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 409.2°Cat760mmHg
• Flash Point: 201.3°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 6.63E-07mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: N-[4-(DIMETHYLAMINO)BENZYL]-N-(4-METHOXYPHENYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(DIMETHYLAMINO)BENZYL]-N-(4-METHOXYPHENYL)AMINE(13159-99-4)
• EPA Substance Registry System: N-[4-(DIMETHYLAMINO)BENZYL]-N-(4-METHOXYPHENYL)AMINE(13159-99-4)

Safety Data

• Hazardous Substances Data: 13159-99-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H20N2O/c1-18(2)15-8-4-13(5-9-15)12-17-14-6-10-16(19-3)11-7-14/h4-11,17H,12H2,1-3H3

Upstream product

• 97221-11-9 (E)-4-(((4-methoxyphenyl)imino)methyl)-N,N-dimethylaniline 
• 1749-04-8 N-(4-(N,N-dimethylamino)benzal)-p-anisidine 
• 104-94-9 4-methoxy-aniline 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 400857-73-0 N'-(2,6-diisopropylphenyl)-N-[(4-dimethylaminophenyl)methyl]-N-(4-methoxyphenyl)urea 

Relevant articles and documents

Ruthenium N-Heterocyclic Carbene Complexes for Chemoselective Reduction of Imines and Reductive Amination of Aldehydes and Ketones

Chemoselective reduction of imines to secondary amines is catalyzed efficiently by tethered and untethered, half-sandwich ruthenium N-heterocyclic carbene (NHC) complexes at room temperature. The untethered Ru-NHC complexes are more efficient as catalysts for the reduction of aldimines and ketimines than the tethered complexes. Using the best untethered complex as a catalyst, electronic and steric demands on the reaction was probed using a series of imines. Chemoselectivity of the catalyst towards imine reduction was tested by performing inter and intramolecular competitive reactions in a variety of ways. The catalyst exhibits a very high TON and TOF under anaerobic conditions.

Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation

Iron-catalyzed hydrosilylation of imines to amines using a well-defined iron complex is reported. This method employs relatively mild conditions, by reaction of imine, (EtO)3SiH in a 1 : 2 ratio in the presence of 1 mol% precatalyst ([BIAN]Fe(η6-toluene), 3, BIAN = bis(2,6-diisopropylaniline)acenaphthene) at 70 °C. A broad scope of imines was readily converted into the corresponding secondary amines without the need for precatalyst activators.

Novel 3-substituted urea derivatives and medicinal use thereof

The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compound of the present invention has a C5a receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of diseases or syndromes due to inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis, pancreatitis and the like) due to activation of leukocytes caused by ischemia, trauma, burn, surgical invasion and the like]. In addition, it is useful as an agent for the prophylaxis or treatment of infectious diseases caused by bacteria or virus that invades via a C5a receptor.