4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline

Base Information

• Chemical Name: 4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline
• CAS No.: 13159-99-4
• Molecular Formula: C16H20N2O
• Molecular Weight: 256.348
• European Community (EC) Number: 634-348-5
• DSSTox Substance ID: DTXSID40357626
• Wikidata: Q82137613
• ChEMBL ID: CHEMBL3594268
• Mol file: 13159-99-4.mol

Synonyms:13159-99-4;4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline;N-[4-(dimethylamino)benzyl]-N-(4-methoxyphenyl)amine;4-[(4-methoxyanilino)methyl]-N,N-dimethylaniline;N-{[4-(dimethylamino)phenyl]methyl}-4-methoxyaniline;CHEMBL3594268;4-{[(4-methoxyphenyl)amino]methyl}-N,N-dimethylaniline;Benzenemethanamine, 4-(dimethylamino)-N-(4-methoxyphenyl)-;Oprea1_016005;SCHEMBL856452;DTXSID40357626;RDKKBVHEHXPZQH-UHFFFAOYSA-N;BDBM50498373;AKOS000241600;SB81936;CS-0224163;EN300-11804;SR-01000062499;(4-dimethylaminophenylmethyl) (4-methoxyphenyl)amine;J-523336;SR-01000062499-1;[(4-dimethylaminophenyl)methyl](4-methoxyphenyl)amine;Z57328866

Chemical Property of 4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline

Chemical Property:

• Vapor Pressure: 6.63E-07mmHg at 25°C
• Boiling Point: 409.2°Cat760mmHg
• Flash Point: 201.3°C
• Density: 1.106g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.157563266
• Heavy Atom Count: 19
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

N-{[4-(dimethylamino)phenyl]methyl}-4-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)CNC2=CC=C(C=C2)OC

Technology Process of 4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline

There total 3 articles about 4-(((4-Methoxyphenyl)amino)methyl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-4-(((4-methoxyphenyl)imino)methyl)-N,N-dimethylaniline (97221-11-9) → [(4-dimethylaminophenyl)methyl](4-methoxyphenyl)amine (13159-99-4)

Guidance literature:

With phenylsilane; (1-(3-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)p-cymeneruthenium(II) chloride; In ethanol; at 30 ℃; for 0.0833333h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejic.202000069

Reference yield: 94.0%

4-methoxy-aniline (104-94-9) + 4-dimethylamino-benzaldehyde (100-10-7) → [(4-dimethylaminophenyl)methyl](4-methoxyphenyl)amine (13159-99-4)

Guidance literature:

With phenylsilane; (1-(3-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)p-cymeneruthenium(II) chloride; In ethanol; at 30 ℃; for 0.583333h; Schlenk technique; Inert atmosphere; Molecular sieve;

DOI:10.1002/ejic.202000069

Reference yield:

N-(4-(N,N-dimethylamino)benzal)-p-anisidine (1749-04-8) → [(4-dimethylaminophenyl)methyl](4-methoxyphenyl)amine (13159-99-4)

Guidance literature:

With Mo(CO)₄(di(1-ethylimidazol-2-ylidene)methane); phenylsilane; In ethanol; Reagent/catalyst; Catalytic behavior; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.ica.2018.10.026

upstream raw materials:

4-methoxy-aniline

4-dimethylamino-benzaldehyde

N-(4-(N,N-dimethylamino)benzal)-p-anisidine

(E)-4-(((4-methoxyphenyl)imino)methyl)-N,N-dimethylaniline

Downstream raw materials:

N'-(2,6-diisopropylphenyl)-N-[(4-dimethylaminophenyl)methyl]-N-(4-methoxyphenyl)urea

Refernces

• 1、 Reshi, Noor U Din,Kathuria, Lakshay,Samuelson, Ashoka G.. "Reduction of imines catalysed by NHC substituted group 6 metal carbonyls". . p. 119 - 128. Retrieved 2018/11/03.
• 2、 Xiao, Zhu-Ping,Shi, Wei-Kang,Wang, Peng-Fei,Wei, Wei,Zeng, Xiao-Tong,Zhang, Ji-Rong,Zhu, Na,Peng, Miao,Peng, Bin,Lin, Xiao-Yi,Ouyang, Hui,Peng, Xiao-Chun,Wang, Guang-Cheng,Zhu, Hai-Liang. "Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors". . p. 4508 - 4513. Retrieved 2015/08/03.