13160-56-0

Upstream product

• 123-30-8 4-amino-phenol 
• 122-04-3 4-nitro-benzoyl chloride 
• 2029-61-0 N-hydroxy-N-phenyl-4-nitrobenzamide 
• 100-65-2 N-Phenylhydroxylamine 
• 98-95-3 nitrobenzene 
• 51-78-5 p-aminophenol hydrochloride 

Downstream Products

• 102591-20-8 1-(4-nitro-benzoylamino)-4-(3,4,5-trimethoxy-benzoyloxy)-benzene 
• 90446-41-6 N-(4-Hydroxy-3,5-bis-pyrrolidin-1-ylmethyl-phenyl)-4-nitro-benzamide 
• 1489231-09-5 N-(3-((7H-purin-6-yl)thio)-4-hydroxyphenyl)-4-nitrobenzamide 
• 1489231-05-1 N-(3-((1,3,4-thiadiazol-2-yl)thio)-4-hydroxyphenyl)-4-nitrobenzamide 
• 1489235-57-5 N-(4-hydroxy-3-((5-methyl-1,3,4-thiadiazol-2-yl)thio)phenyl)-4-nitrobenzamide 
• 1489235-56-4 N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-nitrobenzamide 
• 76960-33-3 4-nitro-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzamide 
• 90446-62-1 N-(4-aminobenzoyl)-3,5-bis(pyrrolidinylmethyl)-4-hydroxyaniline 
• 19208-04-9 2-morpholin-4-ylmethyl-4-(4-nitro-benzoylamino)-phenol 

Relevant academic research and scientific papers

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II

A novel series of 4-amino-2-(thio)phenol derivatives were well synthesized. The preliminary biological test revealed that several compounds displayed high specific protein kinase and angiogenesis inhibitory activities compared with previous work mainly because of the substitution of sulfonamide structure for amide fragment. Among which, compound 5i was identified to inhibit protein kinase B/AKT (IC50 = 1.26 μM) and ABL tyrosine kinase (IC 50 = 1.50 μM) effectively. Meanwhile, compound 5i demonstrated competitive in vitro antiangiogenic activities to Pazopanib in both human umbilical vein endothelial cell (HUVEC) tube formation assay and the rat thoracic aorta rings test.

Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 2. Amides

Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the ami