13162-24-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-methyl-5-nitro-pyrimidin-2-amine is used as a key intermediate in the development of antiviral and antibacterial drugs. Its ability to inhibit the growth and replication of certain pathogens makes it a valuable component in the creation of new therapeutics.
Used as a Research Reagent:
In the field of scientific research, 4-chloro-6-methyl-5-nitro-pyrimidin-2-amine serves as a research reagent, aiding in the study of various biological and chemical processes. Its unique structure and properties provide insights into the development of new compounds and understanding their interactions with biological systems.
Used in Chemical Synthesis:
4-Chloro-6-methyl-5-nitro-pyrimidin-2-amine is also utilized in chemical synthesis, where it can be further modified or combined with other compounds to create new molecules with specific properties and applications. Its versatility in synthesis contributes to the discovery and development of novel chemical entities for various industries.

InChI:InChI=1/C5H8ClN5/c1-9-4-2(7)3(6)10-5(8)11-4/h7H2,1H3,(H3,8,9,10,11)

Upstream product

• 4214-85-1 2-amino-4-hydroxy-6-methyl-5-nitropyrimidine 
• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 299916-90-8 2-N-acetylamino-6-methyl-5-nitropyrimidin-4-one 
• 65224-66-0 2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one 
• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 
• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 3977-29-5 2-amino-6-methyl-3H-pyrimidin-4-one 

Downstream Products

• 64440-91-1 4-aziridin-1-yl-6-methyl-5-nitro-pyrimidin-2-ylamine 
• 160948-33-4 2-amino-4-(benzyloxy)-6-methyl-5-nitropyrimidine 
• 58052-68-9 2,5-diamino-4-methyl-6-thioxo-1,6-dihydopyrimidine 
• 861064-80-4 (2,5-diamino-6-methyl-pyrimidin-4-ylmercapto)-acetic acid 
• 7144-21-0 2,5-diamino-4-methyl-6-methylthiopyrimidine 
• 2829-59-6 6-methyl-2,4-diamino-5-nitropyrimidine 
• 100115-65-9 N⁴-benzyloxy-6-methyl-5-nitro-pyrimidine-2,4-diyldiamine 

Relevant academic research and scientific papers

SAR studies on a novel series of human cytomegalovirus primase inhibitors

A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150 nM in both

Process for preparing 2-pyrrolidinyl-1H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism

A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted all, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) ?with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), ?to form a compound of formula (XX) The compound of formula (XX) is N- and O-deprotected to obtain the compound of formula (I).

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.