1316228-22-4

Basic information

• Product Name: tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
• Synonyms: tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
• CAS NO: 1316228-22-4
• Molecular Weight: 358.179
• Mol File: 1316228-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate(1316228-22-4)
• EPA Substance Registry System: tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate(1316228-22-4)

Safety Data

• Hazardous Substances Data: 1316228-22-4(Hazardous Substances Data)

Upstream product

• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1254926-31-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1316228-33-7 C₂₂H₂₃N₅O₂ 

Relevant articles and documents

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.