23612-48-8

Basic information

• Product Name: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-;2-METHYL-1H-PYRROLO[2,3-B]-PYRIDINE;2-Methyl-7-azaindole;2-Methyl-7-azaindole ,99%;2-Methyl-7-azaindole ,98.5%;2-Methyl-7-azaindole, 98.5%, 98.5%
• CAS NO: 23612-48-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Product Categories: Azaindoles
• Mol File: 23612-48-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 136-142℃
• Appearance: /
• Density: 1.17
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.45±0.40(Predicted)
• CAS DataBase Reference: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(23612-48-8)
• EPA Substance Registry System: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(23612-48-8)

Safety Data

• Hazardous Substances Data: 23612-48-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

2-Methyl-7-Azaindole can be used to fingerprint volatile profile of traditional tobacco and e-cigarettes.

InChI:InChI=1/C8H8N2/c1-6-5-7-3-2-4-9-8(7)10-6/h2-5H,1H3,(H,9,10)

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 348640-02-8 1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 39620-04-7 2-amino-3-chloropyridine 
• 74-99-7 prop-1-yne 
• 504-29-0 2-aminopyridine 
• 6302-03-0 1-(pyridin-3-yl)-2-propanone 
• 1019436-10-2 2-methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1437769-26-0 (E)-3-(2-nitroprop-1-enyl)pyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 203635-54-5 3-(prop-1-yn-1-yl)pyridin-2-amine 
• 67-64-1 acetone 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 7546-38-5 2-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine 
• 858275-30-6 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 114570-17-1 ethyl 2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetate 
• 114570-13-7 (2-Methyl-pyrrolo[2,3-b]pyridin-1-yl)-oxo-acetic acid ethyl ester 
• 189089-83-6 1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 872366-87-5 2-methyl-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 748103-67-5 2-methyl-7-(2-phenylethyl)-pyrrolo[2,3-b]pyridine 
• 145933-81-9 2-methyl-7-(2-phenylethyl)pyrrolo[2,3-b]pyridinehydrobromide 
• 23612-49-9 2-ethyl-7-azaindole 
• 7546-52-3 (2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid methyl ester 
• 1256964-50-7 3-iodo-2-methylpyrrolo[2,3-b]pyridine 
• 1254926-31-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1316228-22-4 tert-butyl 3-iodo-2-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 

Relevant articles and documents

A 2 - methyl -7 - aza indole synthesis method (by machine translation)

The invention discloses a 2 - methyl - 7 - aza indole synthesis method, comprises the following steps: the 2 - amino - 3 - chloro pyridine added in DMF, heating to 150 - 220 °C, adding Cp2 ZrCl2 And catalyst, under stirring conditions, adding methylacetylene, reflux reaction 4 - 6 h, after the reaction, filtration, the filtrate is distilled under reduced pressure to remove the DMF, ethyl acetate extraction, recrystallization, extraction, drying, to obtain 2 - methyl - 7 - azaindole. The application of the synthesis method adopts the one-pot synthesis, the operation is simple, without intermediate purification step, high conversion rate of raw materials, and has high economic benefits. (by machine translation)

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.