1316228-41-7

Basic information

• Product Name: C₂₂H₂₃N₅O₃
• Synonyms: C₂₂H₂₃N₅O₃
• CAS NO: 1316228-41-7
• Molecular Weight: 405.456
• Mol File: 1316228-41-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃N₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃N₅O₃(1316228-41-7)
• EPA Substance Registry System: C₂₂H₂₃N₅O₃(1316228-41-7)

Safety Data

• Hazardous Substances Data: 1316228-41-7(Hazardous Substances Data)

Upstream product

• 271-63-6 7-Azaindole 
• 192189-18-7 tert-butyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 
• 23616-57-1 3-iodo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1316228-63-3 3-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.